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1. 发明申请

WO2013133691A1 LIQUID NUTRITIONAL COMPOSITION COMPRISING FREE AMINO ACIDS 审中-公开
标题翻译：包含游离氨基酸的液体营养组合物
公开(公告)号：WO2013133691A1
公开(公告)日：2013-09-12
申请号：PCT/NL2012/050147
申请日：2012-03-09
申请人： N.V. NUTRICIA , LYNCH, Andrew Sean , ANDERS, Simon David
发明人： LYNCH, Andrew Sean , ANDERS, Simon David
IPC分类号： A23L1/29 , A23L1/304 , A23L1/305 , A61P3/00 , A61K31/198 , A61K31/723 , A61K31/732 , A61K31/736
CPC分类号： A23L1/296 , A23L2/02 , A23L2/66 , A23L33/16 , A23L33/175 , A23L33/40 , A23V2002/00 , A23V2200/00 , A23V2200/30 , A23V2200/32 , A23V2250/00 , A23V2250/032 , A23V2250/06 , A23V2250/1578 , A23V2250/161 , A23V2250/506 , A23V2250/5072 , A23V2250/5086 , A23V2250/70 , A61K31/198 , A61K31/723 , A61K31/736 , A61K33/06 , A61K2300/00
摘要： The invention relates to a liquid or gelled pasteurized or sterilized composition comprising free amino acids, calcium, a digestible carbohydrate, and preferably an indigestible carbohydrate, wherein the free amino acids are present in a concentration between 5 and 30g /100ml, and the dry weight of the total composition is at least 40g/100ml, and preferably lower than 60 g/100ml. The composition may in particular be used in the treatment of a human suffering from a disorder selected from the group consisting of phenylketonuria, homocystinuria, maple syrup urine disease, tyrosinaemia, propionic acidaemia, methylmalonic acidaemia, isovaleric acidaemia, urea cycle disorders and glutaric aciduria.
摘要翻译：本发明涉及包含游离氨基酸，钙，可消化的碳水化合物且优选不消化的碳水化合物的液体或凝胶巴氏杀菌或灭菌的组合物，其中游离氨基酸以5至 30g / 100ml，总组合物的干重至少为40g / 100ml，优选低于60g / 100ml。该组合物可特别用于治疗患有选自苯丙酮尿症，高胱氨酸尿症，枫糖尿病，酪氨酸血症，丙酸血症，甲基丙二酸血症，异戊酸血症，尿素循环障碍和戊二酸尿症的病症的人。

2. 发明申请

WO2011089391A1 MAMMALIAN CELL PRESERVATION METHODS 审中-公开
标题翻译： MAMMALIAN CELL保存方法
公开(公告)号：WO2011089391A1
公开(公告)日：2011-07-28
申请号：PCT/GB2011/000072
申请日：2011-01-21
申请人： CAMBRIDGE ENTERPRISE LIMITED , SLATER, Nigel K. H. , LYNCH, Andrew , CHEN, Rongjun
发明人： SLATER, Nigel K. H. , LYNCH, Andrew , CHEN, Rongjun
IPC分类号： A01N1/02
CPC分类号： A01N1/0221
摘要： This invention relates to methods for reversibly permeabilising mammalian cells to preservation agents, such as trehalose, using synthetic polymers. Suitable synthetic polymers include lysine iso- phthalamide polymers, in particular lysine iso-phthalamide polymers pendanted with one or more hydrophobic amino acids, such as leucine or phenylalanine. Polymer-mediated permeability allows cells to be loaded with high concentrations of preservation agents prior to preservation, for example cryopreservation or lyopreservation, and this allows an increased proportion of cells to remain viable following preservation.
摘要翻译：本发明涉及使用合成聚合物将哺乳动物细胞可逆地渗透至保存剂如海藻糖的方法。合适的合成聚合物包括赖氨酸异邻苯二甲酰胺聚合物，特别是被一个或多个疏水性氨基酸（如亮氨酸或苯丙氨酸）悬浮的赖氨酸异邻苯二甲酰胺聚合物。聚合物介导的通透性允许细胞在保存之前装载高浓度的保存剂，例如冷冻保存或冷冻保存，并且这允许增加比例的细胞在保存后保持存活。

3. 发明申请

WO2011152730A2 Stable high lipid liquid formula 审中-公开
标题翻译：稳定的高脂液体配方
公开(公告)号：WO2011152730A2
公开(公告)日：2011-12-08
申请号：PCT/NL2011/050396
申请日：2011-06-06
申请人： N.V. Nutricia , LYNCH, Andrew Sean , ANDERS, Simon , RONALD, Paul
发明人： LYNCH, Andrew Sean , ANDERS, Simon , RONALD, Paul
IPC分类号： A23L1/29 , A23L1/30 , A23L1/305 , A23L1/308 , A61K38/01 , A61K31/20 , A61K31/733 , A61K38/17 , A61K36/48
CPC分类号： A61K9/107 , A23L33/115 , A23L33/12 , A23L33/19 , A23L33/21 , A23L33/22 , A23L33/40 , A23V2002/00 , A61K31/20 , A61K31/733 , A61K36/48 , A61K38/018 , A61K38/1709 , A61K2300/00 , A23V2200/32 , A23V2250/54246 , A23V2250/18 , A23V2250/28 , A23V2250/5062 , A23V2250/5118 , A23V2200/332 , A23V2200/308 , A23V2200/328 , A23V2200/322
摘要： The present invention provides a ketogenic diet in the form of a sterile shelf stable ready to use formula, in particular a tube feed,comprising casein and dietary fibre.
摘要翻译：本发明提供了一种无菌贮存稳定的即用型配方，特别是包含酪蛋白和膳食纤维的管饲料形式的生酮饮食。

4. 发明申请

WO2015070081A1 CENTRIPETAL SEPARATION SYSTEM FOR CLEANING PARTICULATE-PERVADED AIR OR GAS 审中-公开
标题翻译：用于清洁颗粒膨胀的空气或气体的中心分离系统
公开(公告)号：WO2015070081A1
公开(公告)日：2015-05-14
申请号：PCT/US2014/064660
申请日：2014-11-07
申请人： ANDOVER PROTECTION SYSTEMS, LLC , ROSTON, Edward , LYNCH, Andrew , WETJEN, Johnathan
发明人： ROSTON, Edward , LYNCH, Andrew , WETJEN, Johnathan
IPC分类号： B07B7/083
CPC分类号： B01D45/14 , B01D45/16 , B04B2005/125 , F01M13/04 , F01M2013/0422
摘要： Some embodiments provide a centripetal air or gas cleaning apparatus for removing particulates from air or gas. The apparatus comprises an inlet, housing, impeller, clean air outlet, and particulate outlet. The housing has an inner conical surface. The impeller's rotation creates negative pressure towards the inlet that intakes particulate-pervaded air or gas into the housing. The rotation induces an accelerating force that throws the particulate-pervaded air or gas against the housing outer walls. Here, the particulates separate from the air or gas, penetrate a high-pressure zone, and are ejected through the particulate outlet located in the high-pressure zone. The air or gas, having less inertia, deflects away from the high-pressure zone where it is subjected to a centripetal force that drives the air or gas towards the center of the housing behind the impeller where it is ejected through the clean air outlet.
摘要翻译：一些实施例提供了一种用于从空气或气体中去除微粒的向心空气或气体清洁装置。该装置包括入口，壳体，叶轮，清洁空气出口和微粒出口。壳体具有内锥形表面。叶轮的旋转向入口产生负压，将进入外壳的颗粒渗透空气或气体。旋转引起加速力，其将颗粒状渗透的空气或气体撞击壳体外壁。这里，与空气或气体分离的微粒渗入高压区，并通过位于高压区的微粒出口排出。具有较小惯性的空气或气体偏离高压区域，在该高压区域受到向心力的向心力，该向心力驱动空气或气体朝向叶轮后方的壳体的中心，在叶轮的中心处，喷射通过清洁空气出口。

5. 发明申请

WO2008071991A1 TREATMENT OF PERVASIVE DEVELOPMENTAL DISORDERS 审中-公开
标题翻译：治疗恶性发展障碍
公开(公告)号：WO2008071991A1
公开(公告)日：2008-06-19
申请号：PCT/GB2007/004815
申请日：2007-12-14
申请人： SHS INTERNATIONAL LTD , LYNCH, Andrew, Sean , HAMBLETON, Kerry, Louisa , SMITH, Stephen, Leyland
发明人： LYNCH, Andrew, Sean , HAMBLETON, Kerry, Louisa , SMITH, Stephen, Leyland
IPC分类号： A61K31/198 , A61P25/18 , A61K35/68
CPC分类号： A61K31/198 , A23L33/12 , A23L33/135 , A23L33/15 , A23L33/16 , A23L33/175 , A23L33/21 , A23V2002/00 , A61K35/745 , A61K35/747 , A23V2250/06 , A23V2200/3204 , A23V2250/70 , A61K2300/00
摘要： An orally administrable nutritional formulation for use in the treatment of Pervasive Developmental Disorders (e.g. Autism, Asperger disorder or Retts disorder) contains free amino acids as the sole source of protein. The formulation may be administered to the patient as the sole daily source of protein or as a supplemental source of protein.
摘要翻译：用于治疗普遍性发育障碍（例如自闭症，阿斯伯格病或抑制症）的可口服给药的营养制剂含有游离氨基酸作为唯一的蛋白质来源。该制剂可以作为唯一的每日蛋白质来源或作为蛋白质的补充来源施用于患者。

6. 发明申请

WO2005049012A2 MEDICAMENTS FOR USE IN PROMOTING AND MAINTAINING ABSTINENCE 审中-公开
标题翻译：用于促进和维护绝食的药物
公开(公告)号：WO2005049012A2
公开(公告)日：2005-06-02
申请号：PCT/GB2004004787
申请日：2004-11-15
申请人： SHS INT LTD , BONNER ADRIAN , MARTIN COLIN ROBERT , LYNCH ANDREW , DEERING CATHERINE
发明人： BONNER ADRIAN , MARTIN COLIN ROBERT , LYNCH ANDREW , DEERING CATHERINE
IPC分类号： A23L1/302 , A23L1/303 , A23L1/304 , A23L1/305 , A61K31/405 , A61K31/70 , A61K33/00 , A61K38/16 , A61K45/06 , A61P43/00
CPC分类号： A61K45/06 , A23L33/15 , A23L33/155 , A23L33/16 , A23L33/175 , A61K31/405 , A61K31/70 , A61K33/00 , A61K38/16 , A61K2300/00
摘要： Tryptophan is disclosed as the active agent for a medicament for the promotion and/or maintenance of abstinence from an addictive substance, or addictive substances. The additive substance may be alcohol. The supplemental tryptophan changes the profile of kynurenines to a more neuroprotective balance. The treatment results in improvement in cognitive and other neural functions and aids the process of withdrawal and easies the remission phase after withdrawal is complete.
摘要翻译：公开了色氨酸作为用于促进和/或维持禁忌成瘾物质或成瘾物质的药物的活性剂。添加剂物质可以是醇。补充色氨酸将犬尿苷的分布改变为更神经保护平衡。治疗结果提高了认知功能和其他神经功能，有助于戒断过程，并且在戒断完成后容易得到缓解期。

7. 发明申请

WO2005049012A3 TRYPTOPHAN FOR USE IN PROMOTING AND MAINTAINING ABSTINENCE 审中-公开
公开(公告)号：WO2005049012A3
公开(公告)日：2005-06-02
申请号：PCT/GB2004/004787
申请日：2004-11-15
申请人： SHS INTERNATIONAL LTD , BONNER, Adrian , MARTIN, Colin, Robert , LYNCH, Andrew , DEERING, Catherine
发明人： BONNER, Adrian , MARTIN, Colin, Robert , LYNCH, Andrew , DEERING, Catherine
IPC分类号： A61K31/405
摘要： Tryptophan is disclosed as the active agent for a medicament for the promotion and/or maintenance of abstinence from an addictive substance, or addictive substances. The additive substance may be alcohol. The supplemental tryptophan changes the profile of kynurenines to a more neuroprotective balance. The treatment results in improvement in cognitive and other neural functions and aids the process of withdrawal and easies the remission phase after withdrawal is complete.

8. 发明申请

WO2012113572A1 KETOGENIC DIET COMPOSITION FOR THE TREATMENT OF CHEMO THERAPY AND/OR RADIATION THERAPY PATIENTS 审中-公开
标题翻译：用于治疗化疗和/或放射治疗患者的酮化合物饮食组合物
公开(公告)号：WO2012113572A1
公开(公告)日：2012-08-30
申请号：PCT/EP2012/000815
申请日：2012-02-24
申请人： N.V. NUTRICIA , LYNCH, Andrew, Sean
发明人： LYNCH, Andrew, Sean
IPC分类号： A23L1/29 , A61K31/202 , A61P35/00
CPC分类号： A61K38/02 , A23L33/40 , A61K31/20 , A61K31/202 , A61K31/70
摘要： The present invention provides ketogenic compositions for use in the treatment of a cancer patient undergoing chemotherapy or radiation therapy.
摘要翻译：本发明提供了用于治疗经历化疗或放射疗法的癌症患者的生酮组合物。

9. 发明申请

WO2012113415A1 KETOGENIC DIET COMPOSITION FOR THE TREATMENT OF CHEMO THERAPY AND/OR RADIATION THERAPY PATIENTS 审中-公开
标题翻译：用于治疗化疗和/或放射治疗患者的灭菌剂组合物
公开(公告)号：WO2012113415A1
公开(公告)日：2012-08-30
申请号：PCT/EP2011/000905
申请日：2011-02-24
申请人： N.V. NUTRICIA , LYNCH, Andrew Sean
发明人： LYNCH, Andrew Sean
IPC分类号： A23L1/29 , A61K31/202 , A61P35/00
CPC分类号： A61K38/02 , A23L33/40 , A61K31/20 , A61K31/202 , A61K31/70
摘要： The present invention provides ketogenic compositions for use in the treatment of a cancer patient undergoing chemotherapy or radiation therapy.
摘要翻译：本发明提供用于治疗接受化疗或放射治疗的癌症患者的酮生成组合物。

10. 发明申请

WO2011152730A3 Stable high lipid liquid formula 审中-公开
标题翻译：稳定的高脂液体配方
公开(公告)号：WO2011152730A3
公开(公告)日：2012-01-26
申请号：PCT/NL2011050396
申请日：2011-06-06
申请人： NUTRICIA NV , LYNCH ANDREW SEAN , ANDERS SIMON , RONALD PAUL
发明人： LYNCH ANDREW SEAN , ANDERS SIMON , RONALD PAUL
IPC分类号： A23L1/29 , A23L1/30 , A23L1/305 , A23L1/308 , A61K31/20 , A61K31/733 , A61K36/48 , A61K38/01 , A61K38/17
CPC分类号： A61K9/107 , A23L33/115 , A23L33/12 , A23L33/19 , A23L33/21 , A23L33/22 , A23L33/40 , A23V2002/00 , A61K31/20 , A61K31/733 , A61K36/48 , A61K38/018 , A61K38/1709 , A61K2300/00 , A23V2200/32 , A23V2250/54246 , A23V2250/18 , A23V2250/28 , A23V2250/5062 , A23V2250/5118 , A23V2200/332 , A23V2200/308 , A23V2200/328 , A23V2200/322
摘要： The present invention provides a ketogenic diet in the form of a sterile shelf stable ready to use formula, in particular a tube feed,comprising casein and dietary fibre.
摘要翻译：本发明提供了一种无菌贮存稳定的即用型配方，特别是包含酪蛋白和膳食纤维的管饲料形式的生酮饮食。

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